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Cancer Research
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Neuroendocrinology, Cancer Biology Our laboratory studies the anti-cancer effects of natural products (ie, ginseng, devil’s club), their extracts, and active constituents (ie, ginsenosides) on human breast and prostate cancers. In vitro cell culture systems as well as in vivo animal models are utilized to determine the effects of these compounds on cell proliferation and tumor growth and determine mechanisms of action using many different laboratory techniques. Our lab has a secondary interest in cannabinoids and their effects on the neuroendocrine system, feeding behavior and reproduction in cell and animal models.
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 Jodi Huggenvik, Ph.D. Associate Professor. jhuggenvik@siumed.edu |
Molecular Biology, Cancer Biology In collaboration with Dr. Michael Collard’s laboratory, my laboratory is characterizing the protein-protein interactions and DNA binding characteristics of a transcription factor called DEAF-1. Mutations of DEAF-1 have been found in a variety of cancers and we are examining how these changes affect protein function. Students in my lab receive training in mammalian cell culture and learn a broad range of molecular and cellular techniques while investigating the interacting protein partners and genes regulated by DEAF-1. WebPage
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 Mike Collard, Ph.D. Associate Professor. mcollard@siumed.edu |
Cancer Biology, Reproductive Biology Studies in my lab primarily focus on cancer and male reproduction. In collaboration with Jodi Huggenvik, my lab is investigating the function of a transcription factor called DEAF1. DEAF1 will regulate spermatogenesis and tumor formation through genetic and "epigenetic" mechanisms. Epigenetics involves changes in gene expression through DNA methylation, chromatin modification, sub-nuclear compart-mentalization, and protein-protein interaction, and can include phenomena such as parent-of-origin effects (genomic imprinting). Students in my lab receive broad training in molecular and cellular biology, signal transduction, apoptotic pathways, and the use of gene targeting (mouse knockouts) to produce animal models of human cancers. WebPage
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