CURRICULUM VITAE

Xiao-Xin Yan, M.D., M.S.

Research Objectives

Major research interes= ts of our group include (1) neuronal development and pattern formation in mammali= an CNS, and (2) cellular mechanisms underlying neuroplasticity and certain neurological or degenerative diseases. We use neuroanatomic and biochemical approaches to address formation and alteration of particular neuronal populations and circuitries under normal conditions and following various experimental paradigms. In addition, we are undertaken to determine the relationship between neuronal activity/metabolism and amyloidogenesis, and = its implications for Alzheimer's disease development as well as normal neuronal/synaptic plasticity.

Education:

8/1979-7/1984       M.D.= , Hunan Medical University, China

8/1987-7/1990       M.Sc= . in Neurobiology, Hunan Medical Un= iversity, China

Professional Experience:

1984-1995             Instructor then Lecturer, Dept Anat & Neurobiol, Hunan Med Univ, China

1992-1993        &= nbsp;    Visiting Scholar, Imperial Medical College, London, UK

1995-1996        &= nbsp;    Postdoc, Moran Eye Center, University of Utah

1997-2000        &= nbsp;    Postdoc, University of California at Irvine

2001-2004        &= nbsp;    Senior Research Scientist, Dupont Pharma then Bristol-Myers Squibb

2005-        &= nbsp;            Assistant Professor of Anatomy, SIU

Professional Societies= :

9/1997-12/1999     American Epilepsy Society

4/1992-present<= span lang=3DEN-US style=3D'font-family:Times;mso-bidi-font-family:"Times New Rom= an"'>       Inter= national Brain Research Organization (IBRO)

3/1996-present       Socie= ty for Neuroscience

7/2006-present      American Anatomist Association   &nbs= p;                   =             &nb= sp;            =             &nb= sp;            =                     =

Research Grants and Support:

4/1993-3/1996       Natio= nal Natural Sciences Foundation of China, Co-P.I.

1/1995-1/1997       Natio= nal Educational Committee of China, P.I.

7/2005-6/2008       Cent= ral Research Committee, SIU, P.I.

7/2007-6/2009       Illinois Department of Public Health (Alzheimer research), P.I.            =

Publications:

Peer-reviewed Journal Articles (selected):

1.   Y= an XX, Zheng DS & Garey LJ (1992) Prenatal development of GABA immunoreactive = neurons in the human striate cortex. Dev. Brain Res., 65 (2):191-204.

2.   Ya= n XX, Jen LS & Garey LJ (1993) Parasagittal patches in the granular layer of = the developing and adult rat cerebellum as demonstrated by NADPH-diaphorase histochemistry. Neuroreport, 4 (11):1227-1230.

3.   Ya= n XX, Garey LJ & Jen LS (1994) Development of NADPH-diaphorase activity in the rat neocortex. Dev. Brain Res., 79 (1): 29-38.

4.&n= bsp;    Yan XX, Garey LJ & Jen LS (1995) Spatial periodicity of NADPH-diaphorase an= d synaptophysin, but not SNAP-25, reactivity in the monkey cerebellar cortex. Brain Res., 669 (2): 285-290.=

5.   Ya= n XX, Garey LJ, Liang Y, von Bussmann KA & Jen LS (1995) Increased expression= of NADPH-diaphorase in visual cent= ers after unilateral optic nerve transection in the rat. J. Brain Res., 36 (4): 485-488.

6.   Ya= n XX, Jen LS & Garey LJ (1996) NADPH-diaphorase positive neurons in primate c= erebral cortex colocalise with GABA and calcium-binding proteins. Cerebral Cortex, 6 (3): 524-529.

7.   Ya= n XX & Garey LJ (1996) Calretinin immunoreactivity in the monkey and cat cer= ebellum: cellular localization and modular distribution. J. Brain Res., 37 (3): 409-= 419.

8.   Ca= o QL, Yan XX, Luo XG & Garey LJ (1996) Prenatal development of parvalbumin im= munoreactivity in human striate cortex. Cerebral Cortex, 6 (4): 620-630.=

9.   Ya= n XX, Garey LJ & Jen LS (1996) Prenatal development of NADPH-diaphorase neuro= ns in the human prefrontal cortex. Cerebral Cortex, 6 (5): 737-745.

10. Peng ZC, Li XQ, Liang QH, Zhu CX, Luo TL, Yan XX &am= p; Hu SY (1997) Induction of NADPH-diaphorase activity in the forebrain in a m= odel of intracerebral hemorrhage and its inhibition by the traditional Chinese medicine complex Nao Yi An. Brain Res. Bull., 42 (2):119-128.

11. Yan XX & Wiechmann AF (1997) Early expression of recoverin in a unique population of neurons in the developing human retina. Anat. & Embryol., 195 (1): 51-63.

12 Yan XX (= 1997) Prenatal development of calbindin D-28K and parvalbumin in the human retina= . J. Comp. Neurol., 377 (4): 565-576.

13. Yan XX, Cao QL, Luo XG & Garey LJ (1997) Prenatal development of calbindin-D-28K in human visual cortex. Cerebral Cortex, 7(1):57-62.

14. Yan XX, Cariaga WA & Ribak CE (1997) Immunoreactivity for a GABA plasma membrane transporter, GAT-1, in developi= ng rat cerebral cortex: Transient presence in the somata of neocortical and hippocampal interneurons. Dev. Brain Res., 99 (1): 1-19.<= /p>
15. Yan XX & = Garey LJ (1997) Morphological diversity of nitric oxide synthesizing neurons in mammalian neocortex. J. Brain Res., 38 (2): 165-172.

16. Yan XX & Ribak CE (1997) Prenatal development of nicotinamide adenine dinucleotide-diaphorase activity in the human hippocam= pal formation. Hippocampus, 7 (2): 215-231.

17. Yan XX & Garey LJ (1997) NADPH-diaphorase reactivity is reduced in the molecular lay= er but increased in the granular layer of primate cerebellum after prolonged anaesthesia. Neurosci. Lett., 230:125-128.

18. Ribak CE, Yan XX & Giolli RA (1997) Calcitonin gene-related peptide (CGRP) selectively labels accessory optic nuclei and pathway of the rat visual system. Exp. Brain Res, 117 (10):171-177.

19. Yan XX & Garey LJ (1998) Complementary distributions of calbindin, parvalbumin and calretinin in the cerebellar vermis of the adult cat. J. Brain Res., 39 (1): 9-14.=

20. Yan XX & Ribak CE (1998) In= creased expression of GABA membrane transporters, GAT-1 and GAT-3, in deafferented superior colliculus of the rat. Brain Res., 783 (1):63-76.

21. Toth Z, Yan XX, Haftoglou S, Ribak CE & Baram TZ= (1998) Seizure-induced injury: Vulnerability to febrile seizures in an immature rat model. J. Neurosci., 18 (11):4285-4294.

22. Spigelman I, Yan XX, Obenaus A, Lee EYS, Wasterlain = CG & Ribak CE (1998) Granule cells form novel basal dendrites in a rat mod= el of temporal lobe epilepsy. Neurosci., 86 (1):109-120.

23. Yan XX, Toth Z, Schultz L, Ribak CE & Baram TZ (1998) Corticotropin releasing hormone containing neurons in the hippocampal formation: Light and electron microscopic features and colocalization with glutamic decarboxylases and parvalbumin. Hippocampus, 8:231-243.=

24. Yan XX, Schultz L,= Baram TZ & Ribak CE (1998) Colocalization of corticotropin-releasing hormone = with glutamate decarboxylase and calcium-binding proteins in infant rat neocorti= cal interneurons. Exp. Brain Res., 123:334-340.

25. Yan XX & Ribak CE (1998) Developmental expressio= n of GABA transporters, GAT-1 and GAT-3, in the rat cerebellum: Evidence for a transient presence of GAT-1 in Purkinje cells. Dev. Brain Res., 111:253-269= .

26 Yan XX &= amp; Ribak CE (1999) Alteration of GABA transporter expression in the rat cerebr= al cortex following needle puncture and colchicine injection. Brain Res., 816:= 317-328.

27. Tran V, Hatalski CG, Yan XX & Baram TZ (1999) Effects of blocking GABA degradation on CRF gene expression in selected bra= in regions. Epilepsia, 40 (9): 1190-1197.

28. Zhou J, Ribak CE, Yan XX & Giolli RA (1999) CGRP-immunoreactive cells in the accessory optic nuclei of the rat are most= ly GABAergic interneurons and receive direct retinal input . Brain Res., 838:119-130.

29. Lu DH, Lei DL, Luo XG & Yan XX (1999) Calbindin = and parvalbumin expression in prenatal human cerebellum. Chinese J. Neuroanat., 15:227-233.

30. Yan XX, Spigelman I, Tran P & Ribak CE (2001) Atypical features of rodent granule cells: recurrent basal dendrites and ap= ical axons. Anat. & Embryol., 203: 203-209.

31. Yan XX, Najbauer J, Woo CC, Dashtipo= urK, Ribak CE & Leon M (2001) Expression of active caspase-3 in mitotic a= nd postmitotic cells of the rat forebrain. J. Comp. Neurol., 433 (1): 4-22.

32. Deng GM, Vaziri ND, Jabbari, B Ni Z & Yan XX (200= 1) Increased Tyrosine Nitration of the Brain in Chronic Renal Insufficiency: Reversal by Antioxidant Therapy and Angiotensin-Converting Enzyme Inhibitio= n. J. Am. Soc. Nephrol., 12 (9):1892-1899.

33. Najbaur J, Yan XX & Leon M (200= 2) DNA fragmentation cycles during deprived and non-deprived olfactory development. Brain Res., 926 (1-2): 118-125.

34. Dashtipour K, Yan XX, Dinh TT, Okazaki MM, Nadler JV, Ribak CE (2002) A quantitative and morphological analysis of dentate granule cells with recurrent basal dendrites from normal and epileptic rats. Hippocampus, 12:435-444.

35. Li T, Rominger C, Prakash SR, Olson RE, Wong P, Zaczek R & Yu-Wen Li (2004) Binding sites= of = g-secretase inhibitors in rodent brain: Distribution, postnatal development and effect of deafferentation. J. Neurosci., 24 (12): 2942-2952.

36. Yan XX, Xiong K, Luo X= G, Struble RG, Clough RW (2007) beta-secretase expression in normal and functionally deprived rat olfactory bulbs: Inverse correlation with oxidati= ve metabolic activity. J Comp Neurol., 501(1):52-69.

37. Xiong K, Cai H, Luo XG, Strubl= e RG & Clough RW & Yan XX (2007) Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vi= vo in the rat retina. Exp. Brain Res., 181(3):435-46.

38. Xiong K, Clough RW= , Luo XG, Struble RG, Li YM & Yan XX (2007) [3H]-L-685,458 as a radiotracer t= hat maps gamma-secretase complex in the rat brain: Relevance to Abeta production and presence of active presenilin-1 components. Brain Res., 1157:81-91.

Book chapters:

1.   Garey LJ & Yan XX (1993) Maturation of synapses = and GABA-immunoreactive neurons in the perinatal human visual cortex. In D. de Boysson-Bardies et al.   =       (eds): Developmental Neurocognition: Speech and Face Processing in the First Year = of Life, pp41-49, Kluwer Academic Publishers, Netherlands.
2.   Garey LJ & Yan XX (1995) Development of GABAergic neurons in the human visual cortex. In D. Tracey, G. Paxinos and J. Stone (eds): Advances in     = Behavioral Biology, Volume 43, Neurotransmitters in the Human Brain, pp35-40, Plenum Press, New York and London.

3.   Ribak CE & Yan XX (2000)= GABA neurons in the neocortex. In D.L. Martin and R.W. Olsen (eds): GABA in the Nervous System: The View at Fifty Years, Chapter 20, pp355-366, Lippincott-= Williams & Wilkins.